For loratadine, a second-generation antihistamine and a pro-drug of desloratadine, depression is mentioned in the Swiss labelling (12). In the USA product label for Claritin®, the original loratadine brand, depression is reported to have occurred in at least one patient (<2%) during the clinical trials (13).
Can antihistamines make you depressed?
Can antihistamines cause depression? One study of 92 people with chronic itchiness saw that patients who took the antihistamines cetirizine and hydroxyzine reported an increase in depression and anxiety.
What are side effects of loratadine?
Loratadine may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- dry mouth.
- sore throat.
- mouth sores.
- difficulty falling asleep or staying asleep.
Who should not take loratadine?
Conditions: liver failure. liver problems. moderate to severe kidney impairment.
What does loratadine do to your body?
Loratadine is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose. Loratadine is used to treat sneezing, runny nose, watery eyes, hives, skin rash, itching, and other cold or allergy symptoms.
Do antihistamines weaken your immune system?
Most anti-allergy medications do not affect immunity, but it does depend on the medication. Medication such as antihistamines and Montelukast are generally considered safe so you should continue to use these. To the best of our knowledge, there is no reason to think that antihistamines would lower the immune response.
Is it bad to take antihistamine everyday?
“The most common side effects you tend to see are fatigue, headaches, and dry mouth,” says Shih. If you’re someone for whom the benefits of regular antihistamine use far outweighs the occasional minor side effect, longterm use is safe for most adults and children, he adds.17 мая 2018 г.
Should I take loratadine at night or in the morning?
Timing: Take loratadine once a day at the same time each day, either in the morning OR in the evening. You can take loratadine with or without food. Swallow the tablet whole, with a glass of water. Limit drinking alcohol while you are taking loratadine: It may increase your chance of side effects such as sleepiness.
How quickly does loratadine work?
Loratadine reaches peak plasma concentration in 1-2 hours; the metabolite does so in 3-4 hours. Their respective elimination half-lives are about 10 and 20 hours. Onset of action is within 1 hour and duration is at least 24 hours. Once-daily dosing is recommended.
How long does loratadine stay in your system?
The elimination half-life of loratadine is 8–14 hours and that of its metabolite is 17–24 hours, which accounts for the 24-hour duration of action of the drug. Wheal inhibition is detected at 1.5 hours after administration, reaches a peak at 4–6 hours, and may last 36–48 hours.
Can I take loratadine 10 mg twice a day?
No, the maximum recommended daily dose of loratadine is 10mg once daily.
Does loratadine help with mucus?
When they dry out mucus, they can actually thicken it. Newer antihistamines like loratadine (Claritin, Alavert), fexofenadine (Allegra), cetirizine (Zyrtec), levocetirizine (Xyzal), and desloratadine (Clarinex), may be better options and are less likely to cause drowsiness.
Is loratadine bad for your liver?
Loratadine—present in Claritin—may not be safe for people with severe liver conditions. The liver has to break down loratadine. The kidneys break down cetirizine—found in Zyrtec—and the body excretes it in the urine, largely unchanged.
Is loratadine safe to take every day?
Loratadine is usually taken once a day. During the pollen season, your doctor may advise you to take it every day if you suffer from seasonal allergic rhinitis. Although loratadine is unlikely to make you drowsy, some people are susceptible to this effect.
Does loratadine make your heart race?
Tell your doctor if you experience serious side effects of Claritin including fast or uneven heart rate, feeling like you might pass out, jaundice (yellowing of your skin or eyes), or seizures (convulsions).
Does loratadine cause weight gain?
Newer drugs, including cetirizine (Zyrtec), fexofenadine (Allegra) and loratadine (Claritin), are less likely to cause weight gain, according to Long.